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In some embodiments, the carboxyl group of the C-terminus of the peptide is protected with a carboxyl protecting group and/or the Na-amino group of the peptide is protected with an amino protecting group

Cuglievan, B, Kantarjian, HM, Rubnitz, JE, Cooper, T, Zwaan, CM, Pollard, J, DiNardo, C, Kadia, TM, Guest, E, Short, NJ, McCall, DC, Daver, N, Nunez, CA, Haddad, FG, Garcia, MB, Bhalla, K, Maiti, A, Catueno, S, Fiskus, WC, Carter, BZ, Gibson, A, Roth, M, Khazal, SJ, Tewari, P, Abbas, HA, Bourgeois, W, Andreeff, M, Shukla, N, Truong, D, Connors, JS, Ludwig, JA, Stutterheim, J, Salzer, E, Juul-Dam, KL, Sasaki, K, Mahadeo, KM, Tasian, SK, Borthakur, G , Dickson, S, Jain, N, Jabbour, EJ, Meshinchi, S, Garcia-Manero, G, Ravandi, F, Stein, EM, Kolb, EA, Issa, GC

Although his obituary reports that he was born in New York, his death certificate and the online family tree of the Pearson family note that he was born in Donegal County, Ireland

FERROPTOSIS-RELATED SIGNALING PATHWAYS IN CANCER DRUG RESISTANCE Oxidative damage-related signaling pathways Canonical GPX4-regulated signaling pathway GPX4, a key member of the glutathione peroxidase family, plays a critical role in the modulation of ferroptosis by converting lipid hydroperoxides into inert lipid alcohols, thus preventing their accumulation and protecting cellular membranes

doi:10.1006/abbi.1994.1266

10.3233/JAD-2012-120130 27 FerreiraB.MendesF.OsorioN.CaseiroA.GabrielA.ValadoA