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145 The stimulation of glutamine consumption by WNT is mediated by mTORC1 independent of -catenin

Whereas 2-OBA requires esterification for cellular uptake, 2-AB is incorporated directly into cells, followed by an increase in intracellular GSH levels

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Complementary theoretical and experimental studies further suggest that phenotypic mutations, including ribosomal frameshifts and stop-codon readthrough, generate transient proteoforms that can buffer genetic defects, expand functional diversity, and shape long-term protein evolution (Goldsmith and Tawfik, 2009