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Standardised behavioural models in rodent cognition Spatial memory Morris water maze : submerged platform in opaque pool, localisation latency D1-D5, probe test at D6 (platform removal)

Rosenthal SB

Designed for controlled oral-route models, dissolution studies, or protocols where a consistent solid format supports reproducibility

Except for controlled-release medication, disintegration of a solid drug product usually occurs more rapidly than drug dissolution and permeation

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These investigations should include evaluation of different administration routes, treatment frequencies, and treatment durations to optimize therapeutic protocols