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Visible changes may be caused by diluent incompatibility, pH shift, ionic effects, concentration effects, or peptide-specific solubility behaviour

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Experimental Eye Research , 65 (3), 365378

A molecules effect depends not only on its intrinsic biology but on where it goes, how much of it reaches the target tissue, how long it persists, and what else it interacts with along the way

There is also a specific biological reason the systemic route attracted attention