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e , The distances between catalytic residues Sec46 and Trp136 were recorded every 4.8 ps throughout MD simulations of GPX4 WT (PDB: 6HN3), GPX4 K48A , GPX4 K48L , GPX4 K48E , GPX4 K48Q , and GPX4 K48R

The British National Institute for Health and Care Excellence (NICE) advise exploration of a ME/CFS diagnosis when an individual has experienced unexplained tiredness for more than three months, with decreased ability to undertake occupational, educational, social, or personal activities from pre-illness levels, and only when differential diagnoses have been excluded [12, 27]

Identifying these variants can guide dietary recommendations and supplementation with the appropriate form of folate

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Mitochondria and oxygen homeostasis

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