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Conversely, the simultaneous presence of Lewy body pathology and Alzheimer's Disease (AD)-related changes, such as hyperphosphorylated tau protein or A, can also be observed (Fig

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Cornelius, 2001) The N-terminal secretion signal directs protein to the periplasmic space (see Localizing Protein), and translocation across the plasma membrane results in cleavage of the secretion leader sequence