paracetamol and glutathione depletion Too much = dangerous because of how your liver processes it. *Normal dose:* About 90-95% gets broken down safely by glucuronidation + sulfation → non-toxic stuff you pee out. *The problem Refractory high anion gap metabolic
Refractory high anion gap metabolic acidosis due to chronic paracetamol use: a case report Journal of Medical Case Reports Springer Nature Link paracetamol overdose glutathione depletion Comment FEVER for links to alternatives in post Lets go A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N acetyl meta aminophenol (AMAP) Archives of Toxicology Springer Nature Link Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine Tylenol depletes glutathione, leading to liver damage Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine
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