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Acknowledgments Thanks to all reviewers and editors for your excellent work to improve the manuscript

The crucial role of the calcium voltage-gated calcium channel alpha2/delta (Ca v 2 1) subunit in the development of OHP-induced acute and delayed cold hypersensitivity has also been shown in rodents [64, 65]

Particular focus should be placed on interactions between mHTT, the ironmetabolism axis (such as transferrin receptor 1 and hepcidin), and key ferroptosis mediators (GPX4 and Nrf2) to build a dynamic model linking mHTT aggregation, iron dysregulation, and neuronal ferroptosis, and to define subtype-specific vulnerability of MSNs

Table 1 presents the baseline demographic and clinical characteristics

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doi: 10.1038/s41467-023-44421-6 161 KaiserKALoffredoLFSantos-AlexisKRinghamORArpaiaN