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As mitochondria are the primary source of ROS, their function could be compromised by excessive antioxidants

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S -transferase as revealed by X-ray crystallographic analysis of product complexes with the diastereomers of 9-( S -glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene"

Nat Rev Microbiol 15:5563 Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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Thus, reductive stress induced by altered ratios of these three redox couples affects cellular metabolism and vice versa