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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

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G3BP1/2 dKO MES28 GSCs expressing GFP-tagged G3BP1 mutants were treated with 5 Gy IR or 200 M TMZ for 1 h (n = 3)

Diabetes Mellitus Pathophysiology Type 2 diabetes mellitus (T2DM) is a condition caused by insulin resistance (Figure 2), which is defined by the failing responses of cells in the liver, adipose tissue, pancreas, hypothalamus, and skeletal muscles to insulin [25]

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