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Sequence: Gly-His-Lys, with high-affinity Cu(II) binding Plasma levels fall from ~200 ng/mL at age 20 to ~80 ng/mL at 60 Modulates expression of ~4,000 human genes (Pickart et al., 2012) Active in wound-healing, fibroblast proliferation and antioxidant defence assays Sequence H-Gly-His-Lys-OH (Cu complex) Molecular weight 340.39 g/mol (free tripeptide)

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This DMN reduction may optimize cognitive resource allocation by enhancing local neural efficiency

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