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The incidence and mortality rates of cardiovascular diseases are significantly higher in individuals with diabetes compared to non-diabetic individuals

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In Th1 cells, IL-18, particularly in synergy with IL-12 (74), enhanced the production of interferon (IFN)-, which, as a regulator, acts on the overactivation-associated receptor SLAMF7 on RA macrophages to boost macrophage activation and amplify inflammation (75)