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[27] Why must pH be considered when formulating lysine infusions

L o s par metros P K ( E L I S A ) de los estudios en ratones con variantes de F X a se calcularon usa ndo un anlisis no com partim enta do en W i n N o n L i n ( v 5 , 1, Phars ight C o r p

PfGrx-dependent reduction kinetics for glutathionylated monothiol roGFP2 The glutaredoxin-dependent reduction of glutathionylated monothiol roGFP2 variants was analyzed in the presence and absence of GSH (Fig

In agreement, we observed that cellular GSH levels and the ratio of GSH/GSSG were increased in DMF treatment group (Fig

En los ejemplos en el presente documento, los polipptidos de FXa modificados proporcionados en forma activa que contienen una modificacin en la posicin 195 y/o 196 (por ejemplo, con Ile, Val, Ala, Ser o Thr) se vuelven activos mediante activacin por escisin y procesamiento de un zimgeno de FX modificado que contiene un pptido de activacin que corresponde a los restos de aminocidos 143-194 de la secuencia de aminocidos que se muestra en la SEQ ID N o : 134.Further, in some examples herein following the modified FX polypeptides containing a modification at position 195 of Val, Ala, Ser or Thr and / or at position 196 of Ile, Ala, Ser or Thr with reference to the positions shown in SEQ ID NO: 134 (corresponding to residues 16 and 17 by chymotrypsin numbering), the modified FX polypeptide does not contain a heterologous activation peptide of another serine protease to result in a site of protease processing that is not present in the natural factor X

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