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The spectrum of TdNs is broad since they have very versatile structures

Plos One 7, e41680 (2012)

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With this conceptual foundation clarified, we now return to the main subject: as the resident immune sentinels of the central nervous system, microglia constitute the primary line of defense that preserves neural integrity and maintains cerebral homeostasis

Under oxidative stress, Nrf2 is released from Keap1 and translocated to the nucleus, where it binds to the antioxidant response element (ARE) and upregulates the expression of NQO1 and HO-1 (Meng et al., 2014)