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The spatial and functional overlap between reduced m6A marks and impaired TDP-43-RNA interactions suggests a synergistic mechanism: the loss of METTL3-mediated m6A modification may destabilize RNA-protein complexes, exacerbating the inability of TDP-43 to regulate splicing fidelity (Tollervey et al., 2011)

doi: 10.1016/j.cca.2015.07.009 121

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