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It can usually be kept for several months, but it is essential that the extract be checked regularly for signs of spoilage and discarded if there is any change in color, smell or texture [58]

However, the high sequence identity (53%) and the same active site shared between human fumarase and Mtb fumarase pose a challenge in developing anti-tuberculosis drugs targeting this enzyme [287]

Clinical parameters An automated hematology analyzer XE-2100 (Sysmex, Kobe, Japan) was used for the determination of Hemoglobin (Hb)

Similar to other GLP-1 drugs, CagriSema had mild to moderate side effects, which were mainly gastrointestinal (including nausea, vomiting, diarrhea, and constipation) and diminished over time