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[15] The resulting DSIP-CBBBP construct outperformed unmodified DSIP on neurotransmitter restoration in the mouse model, which is the clearest available statement of the problem: the peptide had to be rebuilt to get where it was supposed to act

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The Food and Drug Administration (FDA) has authorized two categories of epigenetic-modifying medications: DNA methylation inhibitors (including 5-azacitidine and Decitabine) and histone deacetylase inhibitors (such as Vorinostat, Belinostat, Romidepsin, and Panobinostat) [20, 21]

At 4 degrees Celsius (refrigerator temperature), hydrolysis proceeds slowly enough that the peptide retains the vast majority of its activity for 28 days

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