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Sane A, Sinnett D, Delvin E, Bendayan M, Marcil V, Menard D, Beaulieu J, Levy E

Melatonin decreases oxidative stress, prevents germ cell apoptosis, and preserves testicular function in heat-exposed mice 19

Melatonin restored the expression of genes involved in glycolysis (HK2, ENO1, PKM1, LDHA) and the TCA cycle (CS, IDH1, SUCLA2, FH, MDH1), reversed HO-induced metabolic disorders, increased the activity of mitochondrial oxidative phosphorylation complexes (II, III, and V), and increased the efficiency of ATP generation to safeguard the energy requirements of oocytes

2.6 Cyclic dipeptides in plant defense and stress mitigation 2.6.1 Family and structure CDPs, also referred to as 2,5-diketopiperazines (DKPs), are the smallest cyclic peptides, characterized by a stable 2,5-DKP ring structure (Mishra et al., 2017)

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Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme