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Eur J Pharm Biopharm 121:113120

Nagendran MV

11 June 2025

[14] In the developmental stages preceding the formation of synaptic contacts, GABA is synthesized by neurons and acts both as an autocrine (acting on the same cell) and paracrine (acting on nearby cells) signalling mediator

A significant caveat of this model of AD is the lack of progressive A accumulation with age of the rat, but snapshots in time can be obtained in a relatively simple and straightforward manner