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In a healthy body, the liver filters out excess copper and releases it through urine

Beyond scavenging ROS and repolarizing macrophages, a major challenge is achieving selective targeting to hypertrophic synovium while sparing surrounding cartilage and bone

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Besides the interferons, cytokines include hematopoietic growth factors (granulocyte colony-stimulating factor [G-CSF], macrophage colony-stimulating factor [M-CSF], and GM-CSF), interleukins, chemotactic factors, chemokines, TNF, and some growth factors