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Evaluation of semen quality, endocrine profile and hypothalamus-pituitary-testis axis in male patients with homozygous -thalassemia major

Rather than simply suppressing these cytokines, selank appears to promote their production within normal physiological ranges, reducing both excessive elevation and inappropriate suppression

Singh M, Das RR

Tomaru, et al

To further explore the mechanism of NOX2 regulation of iBRB, we hypothesized that the NOX2/ET-1 axis regulates the proliferation of microglia (the principal mediator of neuroinflammation) via the MAPK signaling pathway mediating the inflammatory damage to the iBRB in pathologically H-IOP

Oxidative stress leads to mitochondrial damage and dysfunction, and damaged mitochondria produce abnormally increased ROS leading to further aggravation of oxidative stress [44]