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Indeed, compound Z30702029 inhibited GSDME-N-terminal domain-mediated pyroptosis in preclinical experiments (127)

Carrington PE, Sandu C, Wei YF, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y and Werner MH (2005) The three-dimensional structure of FADD defines the relative organization of death receptor and procaspase in the death-inducing signaling complex

Melatonin ameliorates H(2)O(2)-induced oxidative stress through modulation of Erk/Akt/NFkB pathway

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726 When cellular energy demand increases, fatty acids are transported into the mitochondria for -oxidation, where they are converted into acetyl-CoA and subsequently enter the TCA cycle to generate ATP

The ETC consists of 5 multi-enzyme complexes responsible for maintaining the mitochondrial membrane potential and ATP generation