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G Protein-Coupled Receptors (GPCR) Images Overview G protein-coupled receptors (GPCR) 7 transmembrane domain receptors on the cell membrane that sense the external environments ligands activate the G protein by causing a conformational change this change propagates to a second messenger which detaches from the GPCR to carry the signal to other effector proteins 3 types of GPCR second messengers and functions G q activates phospholipase which results in the formation of G s activates adenyl cyclase resulting in G i inhibits adenyl cyclase resulting in Receptor Types Create a free account or log in to see the cards.