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Iron abundance, proneness to oxidative stress, the role of Ca 2+ signaling in cell death, and the capability of other erythroid lineage cells to undergo ferroptosis all together indicate that this iron-driven cell death pathway might exist in RBCs

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We attempted to overcome these limitations by focusing on a single pathway, using an information-based gene-selection algorithm (based on location in autism linkage regions and expression patterns), selecting tag-single-nucleotide polymorphisms (SNPs) to achieve very high coverage of genes and flanking regions, and by evaluating high order genegene interactions using a newly developed method adapted for family data

Quantitative susceptibility mapping (QSM) shows increased regional brain iron that tracks amyloid-related cognitive decline in longitudinal cohorts (Ayton et al., 2017), with elevated hippocampal iron detectable in vivo by MRI (Raven et al., 2013)

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But the low stakes is that you're acting, you're storytelling