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Year : 2016 Computational Modeling of Single Neuron Extracellular Electric Potentials and Network Local Field Potentials using LFPsim Cite this Research Publication : Harilal Parasuram, Bipin G

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At this point, we have previously shown that IGF-I is a main character in restoring mitochondrial dysfunction during aging by increasing mitochondrial membrane potential, reducing oxygen consumption, and increasing ATP synthesis what in turn minimize the c-cytochrome release to the cytoplasm and subsequently promote neural survival by decreasing caspase-induced apoptosis[55, 56], in agreement with in vitro reported works from others[242244]

Shikonin effectively blocked the IKK/IKK complex formation in vitro and in vivo via preventing the IKK-binding domain (NBD) of IKK from entering the hydrophobic pocket of IKK ( Figure 3 ), resulting the inhibition of proliferation, migration, and invasiveness [60]

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The antitumor activity of CHE has been demonstrated in in vitro experiments for cytotoxicity and growth delay against various tumor cell lines (Malikova et al., 2006)