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Zhang Q, Kim Y, Narayanan N (2015) Disease-modifying therapeutic directions for Lewy-body dementias

When these two pathways are activated simultaneously, the effect is multiplicative: GHRH increases the amount of GH released per cell, and GHRP increases the number of responding cells

The number of migrated cells remarkably decreased when ERK1/2 signal pathways were blocked by its inhibitor PD98059 (Figure 7BC)

Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study

Alone this line, a futuristic multigene transfer can be developed to aim multiple targets and pathways to achieve better therapeutic effect

However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)