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Bethanechol chloride does not cross the blood-brain barrier because of its charged quaternary amine moiety

Readers are referred to the Lipid oxidative damage under blue light section for details on protein modifications caused by lipid peroxidation byproducts

10.1111/j.1365-313X.2006.02746.x 16 AsgherM.KhanM

The early-stage patient fibroblasts showed a significantly higher basal respiration than TDP-43 G376D Asymptomatic fibroblasts, but a much lower spare respiratory capacity, whereas late-stage patient fibroblasts behaved as the TDP-43 G376D Asymptomatic fibroblasts, having similar basal respiration, maximal respiration, and spare respiratory capacity (Fig