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doi: 10.1016/j.ebiom.2021.103293

doi: 10.1007/s00198-010-1456-2 97 TangYWuXLeiWPangLWanCShiZet al

doi: 10.1016/j.molcel.2012.09.025 108 NikiE

In the regulatory framework governed by the ATPase copper transporting (ATP7B) protein, a subset of copper ions interacts with 2-globulin, which serves as a precursor to ceruloplasmin, culminating in the formation of this essential copper-containing enzyme (21,22)

Most patients notice sleep changes within a few weeks

All patients who ingest 30 g or 500 mg/kg of modified release paracetamol or have a paracetamol concentration greater than double the nomogram line should receive an increased dose of acetylcysteine (that is 200 mg/kg over 16 hours)