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PubMed ID: 11146367 Heffernan MA et al

Effects complement direct survival signaling providing multi-level neuroprotection

It can lead to apoptosis [4] and necrosis [5] in hair cells through DNA adduct formation [6], mitochondrial dysfunction [7], oxidative stress [8], and inflammatory responses [9]

The esters of alpha-sulfo fatty acids (ester sulfonates), e.g., the alpha-sulfonated methyl esters of hydrogenated coco-, palm nut- or tallow acids are likewise suitable

The polyphenol extract from H

By contrast, deep-learning-based generative models can now interrogate large chemical-biological datasets to uncover structure-activity relationships, generating novel scaffolds with plausible three-dimensional conformations and tailored engagement of both target and E3 ligase, thereby vastly expanding accessible chemical space [62, 282,283,284,285,286,287]