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We used two paradigms for ALA delivery: an intervention paradigm in which DBA/2J mice at 6 months of age received ALA in order to intervene in glaucoma development, and a prevention paradigm in which DBA/2J mice were raised on a diet supplemented with ALA, with the goal of preventing glaucoma development

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Beauchamp and Childress contend that a dialectical relationship exists between ethical principles and ethical dilemmas, whereby the emergence of new ethical issues may necessitate a critical examination and redefinition of ethical principles