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10.1161/CIRCHEARTFAILURE.112.000281 336 WattsG

While severe inborn errors of folate metabolismsuch as those causing homocystinuriaare rare and typically result from deletions or deleterious mutations that abolish enzyme function, their dramatic clinical consequences have underscored the critical importance of this metabolic pathway [1-3]

14 This underscores the importance of avoiding use of nitrous oxide as an anesthetic in people at risk for vitamin B 12 deficiency

Another study used fMRI to analyze whole-brain patterns of activation and also noted that viewing intensely happy faces generated an activity pattern that differentiated bipolar depression from MDD (148)

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