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Most of the time, you can find what caused them

doi: 10.1016/j.cca.2013.11.037 122 TanYMGaoYTeoGKohHTaiEKhooCet al

Hydrogen Peroxide Is a Diffusible Paracrine Signal for the Induction of Epithelial Cell Death by Activated Myofibroblasts

However, in the complex molecular processes that characterize tumorigenesis, iron also plays a central role in ferroptosis, a form of non-apoptotic regulated cell death characterized by the lethal accumulation of lipid peroxidation products and ROS derived from iron metabolism (362, 363)

Lapeyre-Mestre, M

Food Res Int 54 , 711-7 (2013) CrossRef PubMed Google Scholar 270.Rao AR, Sindhuja HN, Dharmesh SM, Sankar KU, Sarada R, Ravishankar GA, Effective inhibition of skin cancer, tyrosinase and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis [J]