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Thus, a combination of low cysteine concentration, a high demand across multiple cellular processes and oxidative stress mediated by a reduction in GSH probably explains the amplified transcriptional response to cysteine deficiency compared with other amino acid deficiencies

10.1111/1541-4337.12246 77 GruppS

A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis