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These cells often work synergistically, despite having distinct energy metabolism profiles (Table 1) (Blanger et al., 2011)

A.BallestrazziA.et al

Overall, the entry of drugs into the CNS depends on the pharmacokinetics (PK) parameters of drugs, such as molecular size, electric charge, lipophilicity, plasma protein binding, affinity to diffusion/active transport systems at the BBB and BCSFB, and pharmacodynamic (PD) factors such as CSF flow in the brain