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Benzodiazepine withdrawal can be a difficult and uncomfortable process, but understanding the timeline of withdrawal can help to make the experience more manageable

doi: 10.1046/j.1365-2249.1998.00482.x 193 Rosa NetoJCLiraFSOyamaLMZanchiNEYamashitaASBatistaMLJr.et al

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In mammalian cells and mice, calcium overload activated TLK2 (the homologue of Drosophila TLK) by enhancing TLK2 phosphorylation, which increases TLK2 kinase activity