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A landmark series of European trials including the ALADIN, SYDNEY, and NATHAN studies investigated oral ALA supplementation at 600 mg per day and found meaningful results in supporting peripheral nerve comfort and function

Choi S Y, Ko E J, Lee Y H, et al

On the other hand, Demircioglu et al

DHODH holds a pivotal position in the biosynthetic pathway of pyrimidine nucleotides, playing a crucial role in the production of DNA and RNA (49), Inhibition of DHODH disrupts this pathway, leading to abnormalities in, or cessation of, pyrimidine nucleotide synthesis

The effect is especially large in more socially anxious individuals (Pause et al., Reference Pause, Adolph, Prehn-Kristensen and Ferstl2009), in whom there is also evidence for early processing bias towards anxious odour and increased allocation of neuronal resources (Pause et al., Reference Pause, Lbke, Laudien and Ferstl2010)