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The globally fitted model correctly captured the more substantial contribution of the RSK to SOS negative feedback strength compared to the positive feedback from ERK to Raf, which resulted in the upregulation of pMEK after inhibition of MEK (Fig

The exact mechanism underlying these effects is not yet fully understood, though researchers suggest a significant role for ROS accumulation caused by AURA-A inhibition [79]

Data hinted that surgical manipulations of the intestines might markedly dampen the contractile responses to both inducements

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Skin thinning, stretch marks, telangiectasia, and hypothalamic-pituitary-adrenal axis suppression are all documented consequences of prolonged steroid use