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A thorough research analysis revealed that the Western diet exacerbated PD progression due to the poor quality of fiber, whereas the Mediterranean diet, high in fiber and polyphenols alleviated the symptoms of PD (142)

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These protective effects are attributed to their ability to scavenge free radicals and reduce oxidative stress, as well as their anti-inflammatory properties

Pro-inflammatory cytokines stimulate corticotropin-releasing hormone (CRH) secretion and impair glucocorticoid receptor signaling, resulting in diminished negative feedback and sustained hypercortisolemia