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Certain genetic variants affecting collagen production and vessel elasticity may predispose some individuals to more frequent or severe bruising

However, a 2025 safety review argued that BPC-157 appears to regulate angiogenesis in a context-dependent manner

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The Atlantic

No FDA status Not FDA-approved Compound AOD-9604 Mechanism Modified GH fragment

Reported benefits (per available research): FDA-approved, clinical-trial-supported reduction of excess visceral abdominal fat in HIV-associated lipodystrophy, the only indication with robust human RCT evidence behind it Studied in a randomized, placebo-controlled trial for possible support of executive function and cognitive performance in healthy older adults and adults with mild cognitive impairment (Baker et al., 2012) Proposed, but far less rigorously studied in healthy or bodybuilding populations, to support lean body mass and body composition changes through GH/IGF-1 axis stimulation