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For example, ribonucleotide reductase, a diiron enzyme necessary for DNA synthesis, is a well-known drug target, with efforts focused on disrupting the active sites iron moieties (Medici et al., 2015)

This effect is achieved through the downregulation of ASCT2 expression in MKN-45 and MKN-28 cells [49]

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An increase in the absorbance at 412 nm was measured after the addition of DTNB