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Description

An Extract of Polygonum Multiflorum Protects against Free Radical Damage Induced by Ultraviolet B Irradiation of the Skin

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IFN- secreted by anti-PD-L1 immunotherapy-activated CD8 + T cells markedly down-regulates SLC3A2 and SLC7A11 expression in tumor cells through the JAK1-STAT1 signaling pathway (SLC3A2 and SLC7A11 are the two subunits that constitute the cystine/glutamate antiporter, known as System Xc ), resulting in reduced cysteine uptake, compromised GPX-4 function, altered mitochondrial activity, heightened lipid peroxidation, and ultimately ferroptosis induction [17, 25]

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10.3389/fnagi.2015.00124 Front

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10.5483/bmbrep.2007.40.1.088 46 SuzukiM.BetsuyakuT.ItoY.NagaiK.NasuharaY.KagaK.et al (2008)

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