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Recent work demonstrated that IL-10 signaling limits the accumulation of saturated very-long-chain (VLC) ceramides to suppress the expression of inflammatory genes in macrophages (73)

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Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity

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Avoid eating meals at least three hours before lying down or going to bed, which can increase the chance of acid flowing backward

C.ZimprichA.PfuhlmannK.BaumannP.GiesertF.KlausV.et al (2017)