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Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

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Water-soluble vitamins (WSVs) primarily serve as cofactors for associated enzymes, which allows them to modify the biological activity of enzymes [40, 41]

But if your diet isnt optimal, or if your body has an underlying issue, it may not absorb enough B12 which can lead to health problems

How many you need will depend on several factors, including your age, activity level, physical health, frequency of injections, and how well your body responds to the treatment

Tips: Combine foods with Vitamin C & E for better absorption