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The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling

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The underlying mechanisms of these effects are diverse and appear to involve the regulation of various molecular targets, including transcription factors (such as nuclear factor-kB)[12] Resveratrol Resveratrol has been shown in the literature to have powerful anti-inflammatory effects which involve multiple pathways including inhibiting NF-kB, inhibiting iNOS (inducible-nitric oxide synthase) expression and inhibiting inflammatory cytokines such as IL-6 in various inflammatory conditions, including multiple sclerosis [13], diabetic neuropathy [14], arthritis [15], autoimmune myocarditis [16], colitis [17], and exerts immunomodu-latory effects both in vitro and in vivo lymphocytic leukemia in lymphocytic leukemia

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Jett et al., PMID 15817669) and ipamorelin's preclinical and Phase 1 work (Raun et al., PMID 9849822