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Unlike GLP-1 agonists, the changes are compositional rather than scale-weight driven: patients may not lose significant total body weight but will show meaningful reduction in waist circumference and visceral fat volume

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Dale Bredesen (07:06): Please continue

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The involvement of neurofibromin in the RAS-MAPK pathway not only increases predisposition to tumors, but is also associated with presence of phenotypic anomalies and learning and memory impairments, a characteristic shared with other RASopathies.6 NF1 is of autosomal dominant transmission, but half the cases are sporadic or de novo, and the patients have no family history of the disease

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