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Abstract Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy

HA-MTX conjugate is expected to exhibit joint tropism because of selective mutual action with overexpressed CD44 receptors on activated macrophages and synovial cells

Complexes were then allowed to dissociate in PBS for 300 s

All of them had central nervous system involvement with evolution into spastic tetraparesis and a declining clinical condition

Y.PengW

We also integrated the latest developments obtained on the role of receptor trafficking in desensitization and tolerance and the concept of biased agonism