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52 In a genetically engineered mouse model of CRC, mice bearing mutations in four genes commonly found in primary human cancers ( Apc fl/fl , Kras LSL-G12D , Tgfbr2 fl/fl and Trp53 fl/fl ) formed metastases

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Mol Cell 11: 619633 Haynes CM, Titus EA, Cooper AA (2004) Degradation of misfolded proteins prevents ERderived oxidative stress and cell death