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Results vary by individual, but many patients see noticeable changes within weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 199

These E3 ligases associate with REV-ERB and mediate its ubiquitination, targeting it for proteasomal degradation following circadian cues such as lithium treatment or serum shock, both of which synchronize circadian oscillations in mammalian cells (Stojkovic et al., 2014