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To investigate the role of ferrous iron, we assessed the relative content of ferrous iron in FAC and erastin treated IB3-1 CF and cognate C38 cells and found that the IB3-1 cells exhibited significantly increased levels of ferrous iron accumulation following FAC and erastin treatment, which was not apparent in C38 cells (Fig

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206,207 In addition, in human atherosclerotic plaques, elevated levels of Cu have been observed

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