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In both trials, Reclast demonstrated a superior and more rapid therapeutic response compared with risedronate and returned more patients to normal levels of bone turnover, as evidenced by biochemical markers of formation (SAP, serum N-terminal propeptide of type I collagen [P1NP]) and resorption (serum CTx 1 [cross-linked C-telopeptides of type I collagen] and urine -CTx)

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This finding has important safety implications, as elevated IGF-1 levels associated with full GH therapy raise concerns about increased cancer risk, particularly for individuals with pre-existing malignancies or strong family histories

Both compounds are typically sold as freeze-dried powders requiring reconstitution with bacteriostatic water prior to use

Berney M, McCarroll P, Glynn L, Lenehan B

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